Rui Vitoria was the man selected to replace Jesus after an impressive four-year spell in charge at Vitoria Guimaraes, and he instantly set about stamping his authority on the squad, insisting on a 4-4-2 formation with two combative central midfielders, which essentially eliminated the need for the playmaker role Talisca had made his own under Jesus.
The Brazil Under-23 international only started three league games in the first half of the 2015-16 campaign, and he was forced to come out and address reports of tension with the new manager. "Every player has to go through such moments" Talisca said in December of that season. "There is insecurity and lack of confidence, but I am working hard. I played more under Jesus, but there is no personal feud with Rui Vitoria."
Talisca scored nine goals in all competitions despite his limited playing time, including a brilliant free-kick against Bayern Munich in the Champions League quarter-finals. Benfica ended up losing that tie 3-2 on aggregate, but earned plenty of plaudits for their surprise run in Europe, and bounced back to clinch their third successive league title.
Vitoria had undoubtedly taken Benfica to another level, and decided that Talisca's services were no longer required ahead of his second season in the dugout. Liverpool and Wolves emerged as suitors for the former Bahia wonderkid, but Besiktas won the race for his signature - agreeing a two-year loan deal with Benfica.
Less than a month later, Talisca came up against his parent club in the Champions League. Benfica were 1-0 up when the Brazilian was introduced to the action as a second-half substitute, and they managed to hold their lead under deep into stoppage-time. However, with seconds remaining, a needless foul gifted Besiktas a 25-yard free-kick, and Talisca stepped up. Inevitably, he was able to whip the ball into the far corner using his instep, and didn't hold back with his celebration before being mobbed by his team-mates.
In his post-match interview with Sport TV, Talisca accused Benfica of not paying him his final salary after the birth of his daughter, before emphatically denying that his exit from the club was financially motivated: "I want to send a message to Benfica management, because they didn't respect me. There were people who criticised me and said that I left Benfica because of money, but that is a lie."
Talisca ended his maiden season at Besiktas with 17 goals and another league title, earning the nickname 'Kiralik Katil' from supporters, which translates to 'Hired Assasin'. He was the top scorer for the club in all competitions in 2017-18, too, but Besiktas dropped a level as a team and they were not able to make his transfer permanent.
Benfica were still determined to offload Talisca, who had burned all of his bridges at Estadio Da Luz, and it was reported that Mourinho reignited his interest in the attacking midfielder, this time as Manchester United boss.
Guangzhou Evergrande beat United to the punch, though, snapping Talisca up on an initial loan deal in June 2018. Four months later he joined them outright for €19m (£17m/$21m), bringing his time in European football to a premature end.